Nanoxidil – Unpopular Hair Loss Solution Superior to Minoxidil?

is nanoxidil effective?

I have never been more motivated to write about hair loss like I am right now. Recently, a friend of mine shared with me some statistics that really threw me in some sort of mental dismay.

And so, I read…

That 35 million men and 21 million women in the US (on the approximate) suffer from hair loss. This in itself is a reason to worry, yet the statistics aren’t getting any better – the numbers will keep on increasing with each passing day.

I also read…

That, about 47 percent of these people with hair loss would give anything, to the extent of spending their life savings, just so that they can restore a full head of hair.

The numbers are quite high, and so are the treatment options. This is why we are talking about one of the most effective medications for treating hair loss – nanoxidil.

What is nanoxidil?

nano formula illustration

In the second day of August 2011, the hair growth developer – Divine Sin Inc.released a new molecule to the market for treating hair loss.

The molecule was a drug which they called nanoxidil. As the story goes, it was developed to surpass the efficacy and tolerability of minoxidil.

Nanoxidil is a new product in the field of medicine. As a result, there are limited studies that elaborate on its use, efficacy and potential side effects.

However, clinical trials and patient reports indicate that it is advantageous because it has a good penetrative potential and the duration of action is pleasantly admirable. It was initially tested with mice.

According to the 2009 KoreMed study, topical nanoxidil (5 %) solution treatment, applied to the dorsal skin, showed significantly higher hair regrowth rate compared with other groups.

Nanoxidil vs. Minoxidil

Of all the medications for hair loss, minoxidil is perhaps the most well-known. It has been in use for close to 40 years now.

According to the brains behind the discovery of minoxidil, Kahn and Grant initially intended that their medication should be used in the management of hypertension. And that is exactly what the FDA approved it for in 1979 – hypertension.

Subsequently, Upjohn was granted the patent by the US Patent Office to use minoxidil as a remedy for hair loss.

With such a rich history, how does minoxidil compare to nanoxidil?

Well, it is true that minoxidil works well for hair loss. However, it also has some undesirable side effects. When you use it, you stand at risk of experiencing headaches, heart problems, local irritation at the site of application and possibly, the development of acne.

It has also been determined that women are more sensitive to minoxidil; hence the reason why it is recommended that women should only use a concentration of 2% on the maximum.

According to the 2017 year articleNew Treatments for Hair Loss“, nanoxidil solution is quite a novelty in hair loss treatment – its structure is very similar to minoxidil’s but molecular weight is lower, which should, theoretically, lead to a better penetration and absorption rate.

As a result, it may surpass the effectiveness of minoxidil in the stimulation of hair growth. Besides, clinical trials and study-based evidence have revealed that nanoxidil has fewer-to-no side effects when compared to minoxidil.

Besides their molecular differences and other differences aforementioned, the lotions of these products also differ significantly.

The Spectral DCN-N lotion for nanoxidil contains other ingredients apart from nanoxidil. These ingredients include:

These ingredients act in unison to promote the penetration of nanoxidil and improve the growth of hair. On the contrary, minoxidil lotion only contains minoxidil.

Is nanoxidil effective? – What studies say…

Nanoxidil is a recent invention and most of the studies about it are still underway. For instance, phase II study from DS Healthcare Group Inc. evaluating the efficacy and safety of nanoxidil in the treatment of mild to moderate androgenic alopecia has yielded some impressive results.

Results of nanoxidil lotion (Spectral DNC-N) in 6 months:

spectral dnc-n results for women hair loss
Source: Vincenzi, C., Marisaldi, B., Tosti, A., & Patel, B. (2019)

The study reveals that those who are using nanoxidil to treat hair loss can achieve up to 28.6% increase in hair growth in just three months after the onset of treatment. From the study, the researchers concluded that nanoxidil not only boosts the hair count and hair density but also reduce any inflammatory processes in the scalp.

The additional ingredients in nanoxidil lotion also ensure a multifocal approach in the management of hair loss.

See, one of the most common causes of hair loss is perifollicular fibrosis. This simply refers to the premature aging of hair root due to the overproduction of collagen, loss of moisture and/or scarring that occur near the hair shaft.

Aminexil, an ingredient in nanoxidil lotion, is a beneficial anti-fibrosis molecule that combats any process of fibrosis that may cause hair loss.

Copper peptides are also anti-inflammatory because they can block the actions of inflammatory cytokines such as interleukin 1 and transforming growth factor-beta (TGF-beta). This explains the anti-inflammatory effect of nanoxidil lotion.

Studies such as the 2009 study posted in KoreaMed journal explain how minoxidil can be very effective in the management of inflammatory processes in the scalp.

Unlike minoxidil which elicits an increased sensitivity among women, the 2019 study shows that nanoxidil is highly effective in the management of early female pattern hair loss without any worry of increased sensitivity.

According to the mentioned study, the vast majority of research subjects experienced noticeably good results and only 3 % of women in the study have seen no change after 6-month treatment.

Change in Global Hair Density from Baseline After 6 Months of Spectral DNC-N Treatment

nanoxidil effectiveness for hair loss pie chart
SOURCE: “Effects of a New Topical Treatment Containing Several Hair Growth Promoters in Women with Early Female Pattern Hair Loss” by Vincenzi et al. (2018)

Studies about nanoxidil are limited. Nevertheless, it suffices to conclude that this medication has little to no side effects at all. Actually, it is recommended that you use nanoxidil if you are experiencing any adverse side effects when you use minoxidil because there are really no reports of side effects among users of nanoxidil.

However, studies are still underway, and they may reveal even the subtlest of the side effects which are currently not identified.

Price of nanoxidil and where to buy it online

One fact about medications for human use is that the FDA will only approve them after extensive clinical trials. It, therefore, goes without saying that it may take some time before nanoxidil is approved by the FDA.

For this reason, this product is in limited supply, and the stock is also not that large in major online stores like

You can always make a purchase from one of the major drug stores, online stores or visit the DS Laboratories in 1601 Green Rd, Pompano Beach – Florida.

Besides, you may purchase nanoxidil from DS Laboratories using their online store. A three-month formula goes for about 98 dollars or 35 dollars a month on average, which is slightly more expensive than what minoxidil would cost you.

You can order SPECTRAL. DNC-N® (Nanoxidil® 5%) directly from the manufacturer using the link below:

Check the price
spectral dnc-n nanoxidil

But, it is worth the cost?

Personally, I think it is worth it. Considering that you will be experiencing a heightened response to hair loss treatment and close to no side effects of the medication.

Final word

As much as nanoxidil appears to be very effective and a preferable choice to minoxidil, you should be wary about changing medications. If minoxidil is working well for you and you can tolerate the side effects, then there is no need of changing drastically to nanoxidil.

However, if you are starting out on hair loss treatment, then nanoxidil is the preferable choice for you. You can also opt for nanoxidil if minoxidil is giving you side effects that you can’t tolerate.

Finally, your safety is almost always guaranteed if you consult a professional such as your doctor before you consider any of these medications for hair loss.

  • Park, D. H., Oh, C. H., & Chae, M. H. (2009). Correlationship between Hair Growth and IGF-1 and TGF-beta1 Levels. J Korean Soc Aesthetic Plast Surg, 15(1), 64.
  • Patel, Brijesh & Velasco, Maria & Tamez, Fernando. (2016). Phase II Study to Evaluate Efficacy and Safety of SPECTRAL.DNC-N Topical Solution For the Treatment of Mild to Moderate Androgenic Alopecia.
  • Vañó-Galván, S., & Camacho, F. (2017). New treatments for hair loss. Actas Dermo-Sifiliográficas (English Edition), 108(3), 221-228. DOI:
  • Vincenzi, C., Marisaldi, B., Tosti, A., & Patel, B. (2019). Effects of a New Topical Treatment Containing Several Hair Growth Promoters in Women with Early Female Pattern Hair Loss. Skin appendage disorders, 5(3), 146-151. DOI:

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